USC-OGP 2-DE database Two-dimensional polyacrylamide gel electrophoresis database

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Searching in 'USC-OGP 2-DE database' for entry matching: PSME2_HUMAN USC-OGP 2-DE database:  PSME2_HUMAN PSME2_HUMAN General information about the entry View entry in simple text format Entry name PSME2_HUMAN Primary accession number Q9UL46 integrated into USC-OGP 2-DE database on  January 17, 2017 (release 1) 2D Annotations were last modified on January 17, 2017 (version 1) General Annotations were last modified on  April 5, 2017 (version 2) Name and origin of the protein Description RecName: Full=Proteasome activator complex subunit 2; AltName: Full=11S regulator complex subunit beta; Short=REG-beta; AltName: Full=Activator of multicatalytic protease subunit 2; AltName: Full=Proteasome activator 28 subunit beta; Short=PA28b; Short=PA28beta;. Gene name Name=PSME2 Annotated species Homo sapiens (Human) [TaxID: 9606] Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. References [1]   2D GEL CHARACTERIZATION Author 1., Author 2. Submitted (Mar-2011) to Current 2D PAGE maps for identified proteins How to interpret a protein PLATELET_4-7 {PLATELET 4-7} Homo sapiens (Human)   map experimental info   PLATELET_4-7 MAP LOCATIONS: SPOT OGP-0486: pI=5.27; Mw=30221 PLATELET_5-6 {PLATELET 5-6} Homo sapiens (Human)   map experimental info   PLATELET_5-6 MAP LOCATIONS: SPOT OGP-0769: pI=5.24; Mw=30825 UVEAL_MELANOMA_3-10 {UVEAL MELANOMA 3-10} Homo sapiens (Human)   map experimental info   UVEAL_MELANOMA_3-10 MAP LOCATIONS: SPOT OGP-1256: pI=5.39; Mw=30456 Cross-references UniProtKB/Swiss-Prot Q9UL46; PSME2_HUMAN. 2D PAGE maps for identified proteins How to interpret a protein map You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw. Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly. Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed. External data extracted from UniProtKB/Swiss-Prot Extracted from UniProtKB/Swiss-Prot, release: 0.0 Entry name PSME2_HUMAN Primary accession number Q9UL46 Secondary accession number(s) Q15129 Sequence was last modified on  May 18, 2010 (version 4) Annotations were last modified on  March 15, 2017 (version 159) Name and origin of the protein Description RecName: Full=Proteasome activator complex subunit 2; AltName: Full=11S regulator complex subunit beta; Short=REG-beta; AltName: Full=Activator of multicatalytic protease subunit 2; AltName: Full=Proteasome activator 28 subunit beta; Short=PA28b; Short=PA28beta; Gene name Name=PSME2 Encoded on Name=PSME2 Keywords Acetylation; Complete proteome; Direct protein sequencing; Phosphoprotein; Polymorphism; Proteasome; Reference proteome. Copyright Copyrighted by the UniProt Consortium, see http://www.uniprot.org/help/license. Distributed under the Creative Commons Attribution-NoDerivs License Cross-references EMBL AF079558; AAF02218.1; -; Genomic_DNA EMBL D45248; BAA08205.1; -; mRNA EMBL AL136295; -; NOT_ANNOTATED_CDS; Genomic_DNA EMBL BC004368; AAH04368.1; -; mRNA EMBL BC019885; AAH19885.1; -; mRNA EMBL BC072025; AAH72025.1; -; mRNA CCDS CCDS9614.1; -; . PIR I53518; I53518; . RefSeq NP_002809.2; NM_002818.2; . UniGene Hs.434081; -; . UniGene Hs.512410; -; . ProteinModelPortal Q9UL46; -; . SMR Q9UL46; -; . BioGrid 111693; 56; . IntAct Q9UL46; 23; . MINT MINT-1478095; -; . STRING 9606.ENSP00000216802; -; . iPTMnet Q9UL46; -; . PhosphoSitePlus Q9UL46; -; . SwissPalm Q9UL46; -; . BioMuta PSME2; -; . DMDM 296453017; -; . OGP Q9UL46; -; . REPRODUCTION-2DPAGE IPI00384051; -; . EPD Q9UL46; -; . MaxQB Q9UL46; -; . PaxDb Q9UL46; -; . PeptideAtlas Q9UL46; -; . PRIDE Q9UL46; -; . TopDownProteomics Q9UL46; -; . DNASU 5721; -; . Ensembl ENST00000216802; ENSP00000216802; ENSG00000100911; . GeneID 5721; -; . KEGG hsa:5721; -; . UCSC uc001wmj.4; human; . CTD 5721; -; . DisGeNET 5721; -; . GeneCards MIR7703; -; . GeneCards PSME2; -; . HGNC HGNC:9569; PSME2; . HPA HPA062661; -; . MIM 602161; gene; . neXtProt NX_Q9UL46; -; . OpenTargets ENSG00000100911; -; . PharmGKB PA33915; -; . eggNOG KOG4470; Eukaryota; . eggNOG ENOG410XQVX; LUCA; . GeneTree ENSGT00510000046374; -; . HOGENOM HOG000282822; -; . HOVERGEN HBG053745; -; . InParanoid Q9UL46; -; . KO K06697; -; . PhylomeDB Q9UL46; -; . TreeFam TF106236; -; . Reactome R-HSA-1169091; Activation of NF-kappaB in B cells; . Reactome R-HSA-1234176; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; . Reactome R-HSA-1236974; ER-Phagosome pathway; . Reactome R-HSA-1236978; Cross-presentation of soluble exogenous antigens (endosomes); . Reactome R-HSA-174084; Autodegradation of Cdh1 by Cdh1:APC/C; . Reactome R-HSA-174113; SCF-beta-TrCP mediated degradation of Emi1; . Reactome R-HSA-174154; APC/C:Cdc20 mediated degradation of Securin; . Reactome R-HSA-174178; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; . Reactome R-HSA-174184; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; . Reactome R-HSA-180534; Vpu mediated degradation of CD4; . Reactome R-HSA-180585; Vif-mediated degradation of APOBEC3G; . Reactome R-HSA-187577; SCF(Skp2)-mediated degradation of p27/p21; . Reactome R-HSA-195253; Degradation of beta-catenin by the destruction complex; . Reactome R-HSA-202424; Downstream TCR signaling; . Reactome R-HSA-211733; Regulation of activated PAK-2p34 by proteasome mediated degradation; . Reactome R-HSA-2467813; Separation of Sister Chromatids; . Reactome R-HSA-2871837; FCERI mediated NF-kB activation; . Reactome R-HSA-349425; Autodegradation of the E3 ubiquitin ligase COP1; . Reactome R-HSA-350562; Regulation of ornithine decarboxylase (ODC); . Reactome R-HSA-382556; ABC-family proteins mediated transport; . Reactome R-HSA-450408; AUF1 (hnRNP D0) binds and destabilizes mRNA; . Reactome R-HSA-4608870; Asymmetric localization of PCP proteins; . Reactome R-HSA-4641257; Degradation of AXIN; . Reactome R-HSA-4641258; Degradation of DVL; . Reactome R-HSA-5358346; Hedgehog ligand biogenesis; . Reactome R-HSA-5362768; Hh mutants that don't undergo autocatalytic processing are degraded by ERAD; . Reactome R-HSA-5607761; Dectin-1 mediated noncanonical NF-kB signaling; . Reactome R-HSA-5607764; CLEC7A (Dectin-1) signaling; . Reactome R-HSA-5610780; Degradation of GLI1 by the proteasome; . Reactome R-HSA-5610783; Degradation of GLI2 by the proteasome; . Reactome R-HSA-5610785; GLI3 is processed to GLI3R by the proteasome; . Reactome R-HSA-5632684; Hedgehog 'on' state; . Reactome R-HSA-5658442; Regulation of RAS by GAPs; . Reactome R-HSA-5668541; TNFR2 non-canonical NF-kB pathway; . Reactome R-HSA-5676590; NIK-->noncanonical NF-kB signaling; . Reactome R-HSA-5678895; Defective CFTR causes cystic fibrosis; . Reactome R-HSA-5687128; MAPK6/MAPK4 signaling; . Reactome R-HSA-5689603; UCH proteinases; . Reactome R-HSA-5689880; Ub-specific processing proteases; . Reactome R-HSA-68827; CDT1 association with the CDC6:ORC:origin complex; . Reactome R-HSA-68949; Orc1 removal from chromatin; . Reactome R-HSA-69017; CDK-mediated phosphorylation and removal of Cdc6; . Reactome R-HSA-69229; Ubiquitin-dependent degradation of Cyclin D1; . Reactome R-HSA-69481; G2/M Checkpoints; . Reactome R-HSA-69601; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; . Reactome R-HSA-8852276; The role of GTSE1 in G2/M progression after G2 checkpoint; . Reactome R-HSA-8854050; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; . Reactome R-HSA-983168; Antigen processing: Ubiquitination & Proteasome degradation; . ChiTaRS PSME2; human; . GeneWiki PSME2; -; . GenomeRNAi 5721; -; . PRO PR:Q9UL46; -; . Proteomes UP000005640; Chromosome 14; . Bgee ENSG00000100911; -; . CleanEx HS_PSME2; -; . ExpressionAtlas Q9UL46; baseline and differential; . Genevisible Q9UL46; HS; . GO GO:0005737; C:cytoplasm; IBA:GO_Central; . GO GO:0005829; C:cytosol; TAS:Reactome; . GO GO:0070062; C:extracellular exosome; IDA:UniProtKB; . GO GO:0016020; C:membrane; IDA:UniProtKB; . GO GO:0005654; C:nucleoplasm; TAS:Reactome; . GO GO:0008537; C:proteasome activator complex; IEA:InterPro; . GO GO:0000502; C:proteasome complex; TAS:ProtInc; . GO GO:0061133; F:endopeptidase activator activity; IBA:GO_Central; . GO GO:0042802; F:identical protein binding; IPI:IntAct; . GO GO:0031145; P:anaphase-promoting complex-dependent catabolic process; TAS:Reactome; . GO GO:0002479; P:antigen processing and presentation of exogenous peptide antigen via MHC class I; TAP-dependent; TAS:Reactome GO GO:0038095; P:Fc-epsilon receptor signaling pathway; TAS:Reactome; . GO GO:0000165; P:MAPK cascade; TAS:Reactome; . GO GO:0090090; P:negative regulation of canonical Wnt signaling pathway; TAS:Reactome; . GO GO:0010972; P:negative regulation of G2/M transition of mitotic cell cycle; TAS:Reactome; . GO GO:0051436; P:negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; TAS:Reactome; . GO GO:0038061; P:NIK/NF-kappaB signaling; TAS:Reactome; . GO GO:0090263; P:positive regulation of canonical Wnt signaling pathway; TAS:Reactome; . GO GO:0010950; P:positive regulation of endopeptidase activity; IBA:GO_Central; . GO GO:0051437; P:positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition; TAS:Reactome; . GO GO:0043161; P:proteasome-mediated ubiquitin-dependent protein catabolic process; TAS:Reactome; . GO GO:0016579; P:protein deubiquitination; TAS:Reactome; . GO GO:0000209; P:protein polyubiquitination; TAS:Reactome; . GO GO:0006521; P:regulation of cellular amino acid metabolic process; TAS:Reactome; . GO GO:2000045; P:regulation of G1/S transition of mitotic cell cycle; IBA:GO_Central; . GO GO:0043488; P:regulation of mRNA stability; TAS:Reactome; . GO GO:0061136; P:regulation of proteasomal protein catabolic process; IBA:GO_Central; . GO GO:0061418; P:regulation of transcription from RNA polymerase II promoter in response to hypoxia; TAS:Reactome; . GO GO:0031146; P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; TAS:Reactome; . GO GO:0002223; P:stimulatory C-type lectin receptor signaling pathway; TAS:Reactome; . GO GO:0050852; P:T cell receptor signaling pathway; TAS:Reactome; . GO GO:0055085; P:transmembrane transport; TAS:Reactome; . GO GO:0033209; P:tumor necrosis factor-mediated signaling pathway; TAS:Reactome; . GO GO:0060071; P:Wnt signaling pathway; planar cell polarity pathway; TAS:Reactome Gene3D 1.20.120.180; -; 1; . Gene3D 1.20.5.120; -; 1; . InterPro IPR009077; Proteasome_activ_pa28; . InterPro IPR003186; Proteasome_activ_pa28_C; . InterPro IPR003185; Proteasome_activ_pa28_N; . PANTHER PTHR10660; PTHR10660; 1; . Pfam PF02251; PA28_alpha; 1; . Pfam PF02252; PA28_beta; 1; . SUPFAM SSF47216; SSF47216; 1; .

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